Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most common cancers and the fifth leading cause of cancer-related death in men. Immune responses in the tumor microenvironment are hypothesized to be related to the prognosis of PCa patients; however, no studies are available to confirm the same. In this study, we aimed to explore the potential link between these two factors and identify new biomarkers to estimate the survival rate of PCa patients.

Methods

A total of 490 cases were obtained from The Cancer Genome Atlas (TCGA) database. The gene expression data were analyzed by the ESTIMATE algorithm to evaluate the immune and stromal scores. The survival rate was calculated according to the case-specific clinical data. Enrichment analysis was performed to discover the main biolo

SUBMITTER: Sun W 

PROVIDER: S-EPMC7662134 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature