Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers.

ABSTRACT:

Importance

Immune checkpoint inhibitor-induced interstitial lung disease (ICI-ILD) is clinically serious and life-threatening. Preexisting interstitial lung abnormalities have been shown to be risk factors for ICI-ILD in patients with lung cancer.

Objective

To evaluate whether interstitial lung abnormalities are associated with ICI-ILD in patients with nonlung cancers.

Design, setting, and participants

This cohort study was conducted between December 2015 and May 2019 at Hiroshima University Hospital. A total of 199 consecutive patients with head and neck cancer, malignant melanoma, oral cavity cancer, urological cancer, and gastrointestinal cancer who received anti-programmed cell death 1 (PD-1) antibody monotherapy were included. Data analysis was conducted from Dec

SUBMITTER: Shimoji K 

PROVIDER: S-EPMC7662135 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature