Intramacrophage ROS Primes the Innate Immune System via JAK/STAT and Toll Activation.

ABSTRACT: Tissue injury is one of the most severe environmental perturbations for a living organism. When damage occurs in adult Drosophila, there is a local response of the injured tissue and a coordinated action across different tissues to help the organism overcome the deleterious effect of an injury. We show a change in the transcriptome of hemocytes at the site of tissue injury, with pronounced activation of the Toll signaling pathway. We find that induction of the cytokine upd-3 and Toll receptor activation occur in response to injury alone, in the absence of a pathogen. Intracellular accumulation of hydrogen peroxide in hemocytes is essential for upd-3 induction and is facilitated by the diffusion of hydrogen peroxide through a channel protein Prip. Importantly, hemocyte activation and produc

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC7662148 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature