Metabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study.

ABSTRACT:

Background

Low walking ability is highly prevalent with advancing age and predicts major health outcomes. Metabolomics may help to better characterize differences in walking ability among older adults, providing insight into potentially altered molecular processes underlying age-related decline in functioning. We sought to identify metabolites and metabolic pathways associated with high versus low walking ability among 120 participants ages 79-95 from the CHS All Stars study.

Methods

Using a nested case-control design, 60 randomly selected participants with low walking ability were matched one-to-one on age, gender, race, and fasting time with 60 participants with high walking ability. High versus low walking ability was defined as being in the best versus worst tertiles for

SUBMITTER: Marron MM 

PROVIDER: S-EPMC7662173 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature