ResFinder 4.0 for predictions of phenotypes from genotypes.

ABSTRACT:

Objectives

WGS-based antimicrobial susceptibility testing (AST) is as reliable as phenotypic AST for several antimicrobial/bacterial species combinations. However, routine use of WGS-based AST is hindered by the need for bioinformatics skills and knowledge of antimicrobial resistance (AMR) determinants to operate the vast majority of tools developed to date. By leveraging on ResFinder and PointFinder, two freely accessible tools that can also assist users without bioinformatics skills, we aimed at increasing their speed and providing an easily interpretable antibiogram as output.

Methods

The ResFinder code was re-written to process raw reads and use Kmer-based alignment. The existing ResFinder and PointFinder databases were revised and expanded. Additional databases were dev

SUBMITTER: Bortolaia V 

PROVIDER: S-EPMC7662176 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature