Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling.

ABSTRACT: Diabetes is associated with platelet hyper-reactivity and enhanced risk of thrombosis development. Here we compared protein expression in platelets from healthy donors and diabetic patients to identify differentially expressed proteins and their possible function in platelet activation. Mass spectrometry analyses identified cyclin Y (CCNY) in platelets and its reduced expression in platelets from diabetic patients, a phenomenon that could be attributed to the increased activity of calpains. To determine the role of CCNY in platelets, mice globally lacking the protein were studied. CCNY-/- mice demonstrated lower numbers of circulating platelets but platelet responsiveness to thrombin and a thromboxane A2 analogue were comparable with that of wild-type mice, as was agonist-induced α and den

SUBMITTER: Kyselova A 

PROVIDER: S-EPMC7662234 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature