Contradictory Effects of NLRP3 Inflammasome Regulatory Mechanisms in Colitis.

ABSTRACT: The inflammasome is an intracellular molecular complex, which is mainly involved in innate immunity. Inflammasomes are formed in response to danger signals, associated with infection and injury, and mainly regulate the secretion of interleukin-1β and interleukin-18. Inflammasome dysregulation is known to be associated with various diseases and conditions, and its regulatory mechanisms have become of great interest in recent years. In the colon, inflammasomes have been reported to be associated with autophagy and the microbiota, and their dysregulation contributes to colitis and. However, the detailed role of inflammasomes in inflammatory bowel disease is still under debate because the mechanisms that regulate the inflammasome are complex and the inflammasome components and cytokines show s

SUBMITTER: Wagatsuma K 

PROVIDER: S-EPMC7662299 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature