Impact of clinical versus radiographic progression on clinical outcomes in metastatic castration-resistant prostate cancer.

ABSTRACT:

Objectives

Unequivocal clinical progression (UCP)-a worsening of clinical status with or without radiographic progression (RAD)-represents a distinct mode of disease progression in metastatic prostate cancer. We evaluated the prevalence, risk factors and the impact of UCP on survival outcomes.

Methods

A post-hoc analysis of the COU-AA-302, a randomised phase 3 study of abiraterone plus prednisone (AAP) versus prednisone was performed. Baseline characteristics were summarised. Cox proportional-hazards model and Kaplan-Meier method were used for survival and time to event analyses, respectively. Iterative multiple imputation method was used for correlation between clinicoradiographic progression-free survival (crPFS) and overall survival (OS).

Results

Of 736 patients wi

SUBMITTER: Rao A 

PROVIDER: S-EPMC7662417 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature