Use of Nonmedicated Control Substances in Randomized Clinical Trials of Patients With Chronic Rhinosinusitis: A Systematic Review and Single-Arm Meta-analysis.

ABSTRACT:

Importance

The effect of nonmedicated control substances in chronic rhinosinusitis remains unclear.

Objective

To assess the association of nonmedicated control substances in randomized clinical trials with disease outcomes in patients diagnosed with chronic rhinosinusitis.

Data sources and study selection

In this single-arm systematic review and meta-analysis, the Cochrane Library of Systematic Reviews, Ovid MEDLINE, Embase, PubMed, and ClinicalTrials.gov databases were searched for randomized clinical trials with a preintervention and postintervention design for chronic rhinosinusitis that were published between 1946 and January 23, 2019.

Data extraction and synthesis

Paired reviewers independently extracted data. The analyses used random-effects models and th

SUBMITTER: Caulley L 

PROVIDER: S-EPMC7662504 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature