Protocol for a case-control study of vitamin D status, adult multidrug-resistant tuberculosis disease and tuberculosis infection in Mumbai, India.

ABSTRACT:

Introduction

Vitamin D status may be an important determinant of multidrug-resistant tuberculosis (MDR-TB) infection, progression to disease and treatment outcomes. Novel and potentially cost-effective therapies such as vitamin D supplementation are needed to stem the tide of TB and MDR-TB globally, particularly in India, a country that accounts for the largest fraction of the world's TB incidence and MDR-TB incidence, and where vitamin D deficiency is endemic. While vitamin D has shown some promise in the treatment of MDR-TB, its role in the context of MDR-TB infection and progression to disease is largely unknown.

Methods and analysis

Through a case-control study in Mumbai, India, we aim to examine associations between vitamin D status and active MDR-TB and to investigate

SUBMITTER: Mistry N 

PROVIDER: S-EPMC7662534 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature