Aβ-Induced Damage Memory in hCMEC/D3 Cells Mediated by Sirtuin-1.

ABSTRACT: It is well accepted by the scientific community that the accumulation of beta-amyloid (Aβ) may be involved in endothelial dysfunction during Alzheimer's disease (AD) progression; however, anti-Aβ anti-bodies, which remove Aβ plaques, do not improve cerebrovascular function in AD animal models. The reasons for these paradoxical results require investigation. We hypothesized that Aβ exposure may cause persistent damage to cerebral endothelial cells even after Aβ is removed (referred to as cerebrovascular endothelial damage memory). In this study, we aimed to investigate whether cerebrovascular endothelial damage memory exists in endothelial cells. hCMEC/D3 cells were treated with Aβ1-42 for 12 h and then Aβ1-42 was withdrawn for another 12 h incubation to investigate whether cerebrovascular

SUBMITTER: Liu H 

PROVIDER: S-EPMC7662699 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature