Role of Phosphodiesterase in the Biology and Pathology of Diabetes.

ABSTRACT: Glucose metabolism is the initiator of a large number of molecular secretory processes in β cells. Cyclic nucleotides as a second messenger are the main physiological regulators of these processes and are functionally divided into compartments in pancreatic cells. Their intracellular concentration is limited by hydrolysis led by one or more phosphodiesterase (PDE) isoenzymes. Literature data confirmed multiple expressions of PDEs subtypes, but the specific roles of each in pancreatic β-cell function, particularly in humans, are still unclear. Isoforms present in the pancreas are also found in various tissues of the body. Normoglycemia and its strict control are supported by the appropriate release of insulin from the pancreas and the action of insulin in peripheral tissues, including proce

SUBMITTER: Kilanowska A 

PROVIDER: S-EPMC7662747 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature