Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy.

ABSTRACT: Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with

SUBMITTER: Dong L 

PROVIDER: S-EPMC7663685 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature