Developmental Roles of FUSE Binding Protein 1 (Fubp1) in Tooth Morphogenesis.

ABSTRACT: FUSE binding protein 1 (Fubp1), a regulator of the c-Myc transcription factor and a DNA/RNA-binding protein, plays important roles in the regulation of gene transcription and cellular physiology. In this study, to reveal the precise developmental function of Fubp1, we examined the detailed expression pattern and developmental function of Fubp1 during tooth morphogenesis by RT-qPCR, in situ hybridization, and knock-down study using in vitro organ cultivation methods. In embryogenesis, Fubp1 is obviously expressed in the enamel organ and condensed mesenchyme, known to be important for proper tooth formation. Knocking down Fubp1 at E14 for two days, showed the altered expression patterns of tooth development related signalling molecules, including Bmps

SUBMITTER: Aryal YP 

PROVIDER: S-EPMC7663687 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature