Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks.

ABSTRACT: The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various developmental diseases, fibrosis, and tumorigenesis. We now better appreciate the complexity and crosstalk of the Wnt pathway with other signaling cascades. Emerging roles of the Wnt signaling in the cancer stem cell niche and drug resistance have led to development of therapeutics specifically targeting various Wnt components, with some agents currently in clinical trials. This review highlights historical and recent findings on key mediators of Wnt signaling and how they impact antitumor immunity

SUBMITTER: Sharma M 

PROVIDER: S-EPMC7663720 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature