Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?

ABSTRACT: Although the ever-increasing number of cancer patients pose substantial challenges worldwide, finding a treatment with the highest response rate and the lowest number of side effects is still undergoing research. Compared to chemotherapy, the relatively low side effects of cancer immunotherapy have provided ample opportunity for immunotherapy to become a promising approach for patients with malignancy. However, the clinical translation of immune-based therapies requires robust anti-tumoral immune responses. Immune checkpoints have substantial roles in the induction of an immunosuppressive tumor microenvironment and tolerance against tumor antigens. Identifying and targeting these inhibitory axes, which can be established between tumor cells and tumor-infiltrating lymphocytes, can facilitat

SUBMITTER: Hosseinkhani N 

PROVIDER: S-EPMC7663909 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature