Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech.

ABSTRACT:

Background

Childhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies have characterized speech deficits associated with CAS, few studies have examined variability in reading and language and/or other developmental comorbidities. We sought to identify comorbid subgroups within CAS that could be clinically relevant as well as genetically distinctive.

Methods

In a group of 31 children with CAS and 8 controls, we performed hierarchical cluster analysis utilizing measures of articulation, vocabulary, and reading. We also conducted a chart review of the children with CAS to examine other clinical characteristics in these children and their association with subgroup membership.

Re

SUBMITTER: Stein CM 

PROVIDER: S-EPMC7664029 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature