New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior and an unfavorable prognosis rate. Due to the lack of surface receptors, TNBC must be intensely investigated in order to establish a suitable treatment for patients with this pathology. Chemoresistance is an important reason for therapeutic failure in TNBC.

Method

The aim of this study was to investigate the effect of doxorubicin in TNBC cell lines and to highlight cellular and molecular alterations after a long exposure to doxorubicin.

Results

The results revealed that doxorubicin significantly increased the half maximal inhibitory concentration (IC₅₀) values at P12 and P24 compared to parenteral cells P0. Modifications in gene expression were investigated t

SUBMITTER: Ciocan-Cartita CA 

PROVIDER: S-EPMC7664031 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature