Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.

ABSTRACT:

Background

Therapy/prognosis of Non-Small Cell Lung Cancer (NSCLC) patients are strongly related to gene alteration/s or protein expression. However, more than 50% of NSCLC patients are negative to key drugable biomarkers.

Methods

We used human samples of NSCLC and mouse models of lung adenocarcinoma.

Results

We showed that caspase-4 was highly present in the tumor mass compared to non-cancerous human tissues. Interestingly, the orthologue murine caspase-11 promoted lung carcinogenesis in mice. Carcinogen-exposed caspase-11 knockout mice had lower tumor lesions than wild type mice, due to the relevance of caspase-11 in the structural lung cell as demonstrated by bone marrow transplantation and adoptive transfer experiments. Similarly to what observed in mice, caspase-

SUBMITTER: Terlizzi M 

PROVIDER: S-EPMC7664047 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature