Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration.

ABSTRACT:

Background

As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monitor trends in malaria incidence and evaluate community-based interventions.

Methods

Within a mass drug administration (MDA) study in The Gambia, where reduced malaria infection and clinical disease were observed after the intervention, a serological sub-study was conducted in four study villages. Spatio-temporal variation in transmission was measured with a panel of recombinant Pf antigens on a multiplexed bead-based assay. Village-level antibody levels were quantified as under-15 sero-prevalence, sero-conversion rates, and age-adjusted antibody acquisition rates. Antibody levels prior to MDA were assessed for association with persistent malaria infe

SUBMITTER: Wu L 

PROVIDER: S-EPMC7664049 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature