Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection.
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ABSTRACT: Background
Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2.Materials & methods
We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes.Results
Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with six differentially expressed protein-coding genes, and ten host genes that interact with SARS-CoV-2 proteins. Also, they can block the suppressive effect of nine microRNAs induced in viral infections.Conclusion
Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome.
SUBMITTER: Turjya RR
PROVIDER: S-EPMC7664154 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection.
Turjya Rafeed Rahman RR Khan Md Abdullah-Al-Kamran MA Mir Md Khademul Islam Abul Bashar AB
Future virology 20200901 9
<h4>Background</h4>Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2.<h4>Materials & methods</h4>We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes.<h4>Results</h4>Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with ...[more]
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