Levels of brain-derived neurotrophic factor in patients with multiple sclerosis.

ABSTRACT:

Objective

To determine the levels of brain-derived neurotrophic factor (BDNF) in the serum of patients suffering from multiple sclerosis (MS) to evaluate the potential of serum BDNF as a biomarker for MS.

Methods

Using a recently validated enzyme-linked immunoassay (ELISA) we measured BDNF in patients with MS (pwMS), diagnosed according to the 2001 McDonald criteria and aged between 18 and 70 years, participating in a long-term cohort study with annual clinical visits, including blood sampling, neuropsychological testing, and brain magnetic resonance imaging (MRI). The results were compared with an age- and sex-matched cohort of healthy controls (HC). Correlations between BDNF levels and a range of clinical and magnetic resonance imaging variables were assessed using an adju

SUBMITTER: Naegelin Y 

PROVIDER: S-EPMC7664260 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature