Walking in multiple sclerosis improves with tDCS: a randomized, double-blind, sham-controlled study.

ABSTRACT:

Objective

To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS).

Methods

MS participants were recruited for a double-blind, parallel-arm, randomized, sham-controlled trial and assigned to 10 sessions (5 d/wk for 2 weeks) of either active or sham tDCS paired with unloaded cycling for 20 minutes. Stimulation was administered over the left M1 cortex (2.5 mA; anode over C3/cathode over FP2). Gait spatiotemporal parameters were assessed using a wearable inertial sensor (10-meter and 2-minute walking tests). Measurements were collected at baseline, end of tDCS intervention, and 4-week postintervention to test for duration

SUBMITTER: Pilloni G 

PROVIDER: S-EPMC7664269 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature