Effect of plasma exchange in neuromyelitis optica spectrum disorder: A systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct systematic review and meta-analysis for the efficacy of therapeutic plasma exchange (TPE) for neuromyelitis optica spectrum disorder (NMOSD) with an acute attack.

Methods

Systematic review was performed using EMBASE and OVID/Medline database. The eligible studies must be the studies of NMOSD patients treated with TPE during the acute phase. They must report treatment outcomes using either Expanded Disability Status Scale (EDSS) or visual acuity (VA) before and after the therapy. Pooled mean difference (MD) was then calculated by combining MDs of each study using the random-effects model.

Results

Fifteen studies were identified; eleven with 241 NMOSD patients reported EDSS outcome and four studies with 103 NMOSD reported visual outcomes. The meta-a

SUBMITTER: Kosiyakul P 

PROVIDER: S-EPMC7664276 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature