Dataset Information
The neural network basis of altered decision-making in patients with amyotrophic lateral sclerosis.
Ontology highlight
ABSTRACT: Objective
Amyotrophic lateral sclerosis (ALS) is a multisystem disorder associated with motor impairment and behavioral/cognitive involvement. We examined decision-making features and changes in the neural hub network in patients with ALS using a probabilistic reversal learning task and resting-state network analysis, respectively.Methods
Ninety ALS patients and 127 cognitively normal participants performed this task. Data from 62 ALS patients and 63 control participants were fitted to a Q-learning model.Results
ALS patients had anomalous decision-making features with little shift in choice until they thought the value of the two alternatives had become equal. The quantified parameters (Pαβ) calculated by logistic regression analysis with learning rate and inverse temperature well represented the unique choice pattern of ALS patients. Resting-state network analysis demonstrated a strong correlation between Pαβ and decreased degree centrality in the anterior cingulate gyrus and frontal pole.Interpretation
Altered decision-making in ALS patients may be related to the decreased hub function of medial prefrontal areas.
SUBMITTER: Imai K
PROVIDER: S-EPMC7664284 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
The neural network basis of altered decision-making in patients with amyotrophic lateral sclerosis.
Annals of clinical and translational neurology 20201022 11
<h4>Objective</h4>Amyotrophic lateral sclerosis (ALS) is a multisystem disorder associated with motor impairment and behavioral/cognitive involvement. We examined decision-making features and changes in the neural hub network in patients with ALS using a probabilistic reversal learning task and resting-state network analysis, respectively.<h4>Methods</h4>Ninety ALS patients and 127 cognitively normal participants performed this task. Data from 62 ALS patients and 63 control participants were fit ...[more]
