Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial.

ABSTRACT:

Background

Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant.

Research question

Is the clinical application of sigh during pressure support ventilation (PSV) feasible?

Study design and methods

We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pressure to 30 cm H₂O for 3 s once per minute) until day 28 or death o

SUBMITTER: Mauri T 

PROVIDER: S-EPMC7664474 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature