Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.

ABSTRACT: As microbial therapeutics are increasingly being tested in diverse patient populations, it is essential to understand the host and environmental factors influencing the microbiome. Through analysis of 1,359 gut microbiome samples from 946 healthy donors of the Milieu Intérieur cohort, we detail how microbiome composition is associated with host factors, lifestyle parameters, and disease states. Using a genome-based taxonomy, we found biological sex was the strongest driver of community composition. Additionally, bacterial populations shift across decades of life (age 20-69), with Bacteroidota species consistently increased with age while Actinobacteriota species, including Bifidobacterium, decreased. Longitudinal sampling revealed that short-term stability exceeds interindividual differenc

SUBMITTER: Byrd AL 

PROVIDER: S-EPMC7664509 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature