Molecular pathophysiology of diabetes mellitus during pregnancy with antenatal complications.

ABSTRACT: Gestational diabetes mellitus is a daunting problem accompanied by severe fetal development complications and type 2 diabetes mellitus in postpartum. Diagnosis of diabetic conditions occurs only in the second trimester, while associated antenatal complications are typically revealed even later. We acquired an assay of peripheral and cord blood samples of patients with different types of diabetes mellitus who delivered either healthy newborns or associated with fetopathy complications. Obtained data were handled with qualitative and quantitative analysis. Pathways of molecular events involved in diabetes mellitus and fetopathy were reconstructed based on the discovered markers and their quantitative alteration. Plenty of pathways were integrated to differentiate the type of diabetes and to

SUBMITTER: Kopylov AT 

PROVIDER: S-EPMC7665025 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature