Articaine in functional NLC show improved anesthesia and anti-inflammatory activity in zebrafish.

ABSTRACT: Anesthetic failure is common in dental inflammation processes, even when modern agents, such as articaine, are used. Nanostructured lipid carriers (NLC) are systems with the potential to improve anesthetic efficacy, in which active excipients can provide desirable properties, such as anti-inflammatory. Coupling factorial design (FD) for in vitro formulation development with in vivo zebrafish tests, six different NLC formulations, composed of synthetic (cetyl palmitate/triglycerides) or natural (avocado butter/olive oil/copaiba oil) lipids were evaluated for loading articaine. The formulations selected by FD were physicochemically characterized, tested for shelf stability and in vitro release kinetics and had their in vivo effect (anti-inflammatory and anesthetic effect) screened in zebrafi

SUBMITTER: Rodrigues da Silva GH 

PROVIDER: S-EPMC7665027 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature