Ontology highlight
ABSTRACT:
SUBMITTER: Ausina P
PROVIDER: S-EPMC7665072 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ausina Priscila P Branco Jessica R JR Demaria Thainá M TM Esteves Amanda M AM Leandro João Gabriel B JGB Ochioni Alan C AC Mendonça Ana Paula M APM Palhano Fernando L FL Oliveira Marcus F MF Abou-Kheir Wassim W Sola-Penna Mauro M Zancan Patricia P
Scientific reports 20201112 1
Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with multiple applications in medicine. Here, we showed that ASA and SA present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects. In both in vivo and in vitro models, SA and ASA trig ...[more]