Unknown

Dataset Information

0

Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.


ABSTRACT: Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with multiple applications in medicine. Here, we showed that ASA and SA present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects. In both in vivo and in vitro models, SA and ASA triggered endoplasmic reticulum (ER) stress, which culminates with the upregulation of the pro-apoptotic transcription factor C/EBP homologous protein (CHOP). These effects are initiated by ASA/SA-triggered Akt/mTOR/AMPK-dependent activation of nitric oxide synthase 3 (eNOS), which increases nitric oxide and reactive oxygen species production inducing ER stress response. In the end, we propose that ASA and SA instigate anticancer effects by a novel mechanism, the activation of ER stress.

SUBMITTER: Ausina P 

PROVIDER: S-EPMC7665072 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.

Ausina Priscila P   Branco Jessica R JR   Demaria Thainá M TM   Esteves Amanda M AM   Leandro João Gabriel B JGB   Ochioni Alan C AC   Mendonça Ana Paula M APM   Palhano Fernando L FL   Oliveira Marcus F MF   Abou-Kheir Wassim W   Sola-Penna Mauro M   Zancan Patricia P  

Scientific reports 20201112 1


Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with multiple applications in medicine. Here, we showed that ASA and SA present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects. In both in vivo and in vitro models, SA and ASA trig  ...[more]

Similar Datasets

| S-EPMC6928836 | biostudies-literature
| S-EPMC5984531 | biostudies-literature
| S-EPMC6723055 | biostudies-literature
| S-EPMC6719610 | biostudies-literature
| S-EPMC2899892 | biostudies-literature
| S-EPMC3698985 | biostudies-literature
| S-EPMC7322074 | biostudies-literature
| S-EPMC3253999 | biostudies-literature
| S-EPMC4590596 | biostudies-literature
| S-EPMC7165182 | biostudies-literature