Polymeric persulfide prodrugs: Mitigating oxidative stress through controlled delivery of reactive sulfur species.

ABSTRACT: Related biologically to the known gasotransmitter hydrogen sulfide (H₂S), persulfides (R-SSH) have recently been recognized as native signaling compounds and redox regulators in their own right. Reported here is the synthesis, characterization, and in vitro evaluation of a small molecule persulfide donor and its polymeric counterpart, both of which release N-acetyl cysteine persulfide (NAC-SSH) in response to esterases. The donors, termed EDP-NAC and poly(EDP-NAC), underwent controlled decomposition in response to porcine liver esterase, resulting in pseudo-first-order release half-lives of 1.6 h ± 0.3 h and 36.0 h ± 0.6 h, respectively. In cell experiments, slow-releasing poly(EDP-NAC) rescued H9C2 cardiomyocytes more effectively than EDP-NAC when cells were treat

SUBMITTER: Dillon KM 

PROVIDER: S-EPMC7665160 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature