High definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia.

ABSTRACT: Recent findings indicate that measures derived from resting-state magnetoencephalography (rsMEG) are sensitive to cortical dysfunction in post-stroke aphasia. Spectral power and multiscale entropy (MSE) measures show that left-hemispheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing and alterations in signal complexity. In the current study, we tested whether individually-targeted high-definition transcranial direct current stimulation (HD-tDCS) can reduce MEG abnormalities and transiently improve language performance. In eleven chronic aphasia survivors, we devised a method to localize perilesional areas exhibiting peak MSE abnormalities, and subsequently targeted these areas with excitatory/anodal-tDCS, or targeted the contralateral homolog

SUBMITTER: Shah-Basak PP 

PROVIDER: S-EPMC7665190 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature