Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.

ABSTRACT:

Introduction

The aim of this study was to determine the role of hepatitis E virus (HEV) infection in a large cohort of prospectively enrolled patients with severe acute liver injury (ALI).

Methods

Serum samples from 594 consecutive adults enrolled between 2008 and 2018 in the US Acute Liver Failure Study Group ALI registry were tested for anti-HEV IgM and anti-HEV IgG levels. Those with detectable anti-HEV IgM underwent further testing for HEV RNA using real-time polymerase chain reaction.

Results

The median age of patients was 38 years; 41% were men and 72% Caucasian. Etiologies of ALI included acetaminophen hepatotoxicity (50%), autoimmune hepatitis (8.9%), hepatitis B virus (8.9%), and idiosyncratic drug-induced liver injury (7.9%). Overall, 62 patients (10.4%) wer

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC7665257 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature