Commercial Serology Assays Predict Neutralization Activity against SARS-CoV-2.

ABSTRACT:

Background

It is unknown whether a positive serology result correlates with protective immunity against SARS-CoV-2. There are also concerns regarding the low positive predictive value of SARS-CoV-2 serology tests, especially when testing populations with low disease prevalence.

Methods

A neutralization assay was validated in a set of PCR-confirmed positive specimens and in a negative cohort. In addition, 9530 specimens were screened using the Diazyme SARS-CoV-2 IgG serology assay and all positive results (N = 164 individuals) were reanalyzed using the neutralization assay, the Roche total immunoglobin assay, and the Abbott IgG assay. The relationship between the magnitude of a positive SARS-CoV-2 serology result and neutralizing activity was determined. Neutralizing antibody

SUBMITTER: Suhandynata RT 

PROVIDER: S-EPMC7665417 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature