Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to human.

ABSTRACT:

Background

The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome (SARS)-CoV-2, has become the most devastating public health emergency in the 21st century and one of the most influential plagues in history. Studies on the origin of SARS-CoV-2 have generally agreed that the virus probably comes from bat, closely related to a bat CoV named BCoV-RaTG13 taken from horseshoe bat (Rhinolophus affinis), with Malayan pangolin (Manis javanica) being a plausible intermediate host. However, due to the relatively low number of SARS-CoV-2-related strains available in public domain, the evolutionary history remains unclear.

Methodology

Nine hundred ninety-five coronavirus sequences from NCBI Genbank and GISAID were obtained and

SUBMITTER: Lei KC 

PROVIDER: S-EPMC7665476 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature