Dataset Information

Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

ABSTRACT:

Background

This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.

Methods

This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.

Results

145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p<0.001) or with a CRP of 40 mg/l or greater (OR 5.44, 1.18-25.25; p = 0.030) on admission. Patients with more than seven days of symptoms on admission had decreased odds of mechanical ventilation (0.087, 95% CI 0.02-0.38, p = 0.001).

Conclusions

This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.

SUBMITTER: Regina J

PROVIDER: S-EPMC7665644 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

Regina Jean J Papadimitriou-Olivgeris Matthaios M Burger Raphaël R Le Pogam Marie-Annick MA Niemi Tapio T Filippidis Paraskevas P Tschopp Jonathan J Desgranges Florian F Viala Benjamin B Kampouri Eleftheria E Rochat Laurence L Haefliger David D Belkoniene Mehdi M Fidalgo Carlos C Kritikos Antonios A Jaton Katia K Senn Laurence L Bart Pierre-Alexandre PA Pagani Jean-Luc JL Manuel Oriol O Lhopitallier Loïc L

PloS one 20201113 11

<h4>Background</h4>This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.<h4>Methods</h4>This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventil ...[more]

PMID: 33186355

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Dataset Information

Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

Background

Methods

Results

Conclusions

Publications

Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

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