Hippocampal neurons with stable excitatory connectivity become part of neuronal representations.

ABSTRACT: Experiences are represented in the brain by patterns of neuronal activity. Ensembles of neurons representing experience undergo activity-dependent plasticity and are important for learning and recall. They are thus considered cellular engrams of memory. Yet, the cellular events that bias neurons to become part of a neuronal representation are largely unknown. In rodents, turnover of structural connectivity has been proposed to underlie the turnover of neuronal representations and also to be a cellular mechanism defining the time duration for which memories are stored in the hippocampus. If these hypotheses are true, structural dynamics of connectivity should be involved in the formation of neuronal representations and concurrently important for learning and recall. To tackle these question

SUBMITTER: Castello-Waldow TP 

PROVIDER: S-EPMC7665705 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature