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Revisiting Settlement Contemporaneity and Exploring Stability and Instability: Case Studies from the Indus Civilization.

ABSTRACT: "Map overestimation," or "the contemporaneity problem," derives from the assumption that settlements identified during surface surveys were occupied throughout individual periods. Inductive and simulation analysis have been used to ascertain the degree of contemporaneity in surface survey data sets, as variation in settlement location is critical for understanding population density and demography, which inform social, economic and political interpretations. This paper revisits the inductive approach to interrogating survey data developed by W. M. Sumner and the simulation model approach developed by R. E. Dewar to explore the survey data from two regions within South Asia's Indus civilization. This analysis demonstrates the strengths and weaknesses of these approaches. It also highlights the variability in settlement systems in different areas within the Indus civilization and shows that consideration of stability and instability within settlement systems is an important factor when considering dynamics of resilience and sustainability.

SUBMITTER: Petrie CA

PROVIDER: S-EPMC7665820 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Revisiting Settlement Contemporaneity and Exploring Stability and Instability: Case Studies from the Indus Civilization.

Petrie Cameron A CA Lynam Frank F

Journal of field archaeology 20190930 1

"Map overestimation," or "the contemporaneity problem," derives from the assumption that settlements identified during surface surveys were occupied throughout individual periods. Inductive and simulation analysis have been used to ascertain the degree of contemporaneity in surface survey data sets, as variation in settlement location is critical for understanding population density and demography, which inform social, economic and political interpretations. This paper revisits the inductive app ...[more]

PMID: 33239833

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Project description:In 2013, we published a comparative analysis of mutation and gene expression profiles and drug sensitivity measurements for 15 drugs characterized in the 471 cancer cell lines screened in the Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE). While we found good concordance in gene expression profiles, there was substantial inconsistency in the drug responses reported by the GDSC and CCLE projects. We received extensive feedback on the comparisons that we performed. This feedback, along with the release of new data, prompted us to revisit our initial analysis. We present a new analysis using these expanded data, where we address the most significant suggestions for improvements on our published analysis - that targeted therapies and broad cytotoxic drugs should have been treated differently in assessing consistency, that consistency of both molecular profiles and drug sensitivity measurements should be compared across cell lines, and that the software analysis tools provided should have been easier to run, particularly as the GDSC and CCLE released additional data. Our re-analysis supports our previous finding that gene expression data are significantly more consistent than drug sensitivity measurements. Using new statistics to assess data consistency allowed identification of two broad effect drugs and three targeted drugs with moderate to good consistency in drug sensitivity data between GDSC and CCLE. For three other targeted drugs, there were not enough sensitive cell lines to assess the consistency of the pharmacological profiles. We found evidence of inconsistencies in pharmacological phenotypes for the remaining eight drugs. Overall, our findings suggest that the drug sensitivity data in GDSC and CCLE continue to present challenges for robust biomarker discovery. This re-analysis provides additional support for the argument that experimental standardization and validation of pharmacogenomic response will be necessary to advance the broad use of large pharmacogenomic screens.

Dataset Information

Revisiting Settlement Contemporaneity and Exploring Stability and Instability: Case Studies from the Indus Civilization.

Publications

Revisiting Settlement Contemporaneity and Exploring Stability and Instability: Case Studies from the Indus Civilization.

Similar Datasets

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