In Situ Formation of Polymeric Nanoassemblies Using an Efficient Reversible Click Reaction.

ABSTRACT: Polymer-drug conjugates are promising as strategies for drug delivery, because of their high drug loading capacity and low premature release profile. However, the preparation of these conjugates is often tedious. In this paper, we report an efficient method for polymer-drug conjugates using an ultrafast and reversible click reaction in a post-polymerization functionalization strategy. The reaction is based on the rapid condensation of boronic acid functionalities with salicylhydroxamates. The polymer, bearing the latter functionality, has been designed such that the reaction with boronic acid bearing drugs induces an in situ self-assembly of the conjugates to form well-defined nanostructures. We show that this method is not only applicable for molecules with an intrinsic boronic acid group

SUBMITTER: Liu B 

PROVIDER: S-EPMC7666047 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature