Hippocampal CA2 sharp-wave ripples reactivate and promote social memory.

ABSTRACT: The consolidation of spatial memory depends on the reactivation ('replay') of hippocampal place cells that were active during recent behaviour. Such reactivation is observed during sharp-wave ripples (SWRs)-synchronous oscillatory electrical events that occur during non-rapid-eye-movement (non-REM) sleep^1-8 and whose disruption impairs spatial memory^3,5,6,8. Although the hippocampus also encodes a wide range of non-spatial forms of declarative memory, it is not yet known whether SWRs are necessary for such memories. Moreover, although SWRs can arise from either the CA3 or the CA2 region of the hippocampus^7,9, the relative importance of SWRs from these regions for memory consolidation is unknown. Here we examine the role of SWRs during the consolidation of s

SUBMITTER: Oliva A 

PROVIDER: S-EPMC7666067 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature