Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure.

ABSTRACT: Commensal gut microbiota are strongly correlated with host hemodynamic homeostasis but only broadly associated with cardiovascular health. This includes a general correspondence of quantitative and qualitative shifts in intestinal microbial communities found in hypertensive rat models and human patients. However, the mechanisms by which gut microbes contribute to the function of organs important for blood pressure (BP) control remain unanswered. To examine the direct effects of microbiota on BP, we conventionalized germ-free (GF) rats with specific pathogen-free rats for a short-term period of 10 days, which served as a model system to observe the dynamic responses when reconstituting the holobiome. The absence of microbiota in GF rats resulted with relative hypotension compared with their

SUBMITTER: Joe B 

PROVIDER: S-EPMC7666075 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature