Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods.

ABSTRACT: Metabolic engineering of mammalian cells has to-date focused primarily on biopharmaceutical protein production or the manipulation of native metabolic processes towards therapeutic aims. However, significant potential exists for expanding these techniques to diverse applications by looking across the taxonomic tree to bioactive metabolites not synthesized in animals. Namely, cross-taxa metabolic engineering of mammalian cells could offer value in applications ranging fromfood and nutrition to regenerative medicine and gene therapy. Towards the former, recent advances in meat production through cell culture suggest the potential to produce meat with fine cellular control, where tuning composition through cross-taxa metabolic engineering could enhance nutrition and food-functionality. Here w

SUBMITTER: Stout AJ 

PROVIDER: S-EPMC7666109 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature