Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study.

ABSTRACT: The analysis of the effects of autozygosity, measured as the change of the mean value of a trait among offspring of genetic relatives, reveals the existence of directional dominance or overdominance. In this study we detect evidence of the effect of autozygosity in 4 out of 13 cardiometabolic disease-associated traits using data from more than 10,000 sub-Saharan African individuals recruited from Ghana, Burkina Faso, Kenya and South Africa. The effect of autozygosity on these phenotypes is found to be sex-related, with inbreeding having a significant decreasing effect in men but a significant increasing effect in women for several traits (body mass index, subcutaneous adipose tissue, low-density lipoproteins and total cholesterol levels). Overall, the effect of inbreeding depression is mor

SUBMITTER: Ceballos FC 

PROVIDER: S-EPMC7666169 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature