Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [¹¹C]UCB-J PET study in a model of obsessive-compulsive disorder-like behaviour.

ABSTRACT:

Background

Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders-including obsessive-compulsive disorder (OCD)-is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([¹¹C]UCB-J) provides the opportunity to visualize synaptic density changes in vivo, by targeting the synaptic vesicle protein 2A (SV2A). Here, we aim to evaluate such alterations in the brain of the SAP90/PSD-95-associated protein 3 (Sapap3) knockout (ko) mouse model, showing an abnormal corticostriatal neurotransmission resulting in OCD-like behaviour.

Methods

Longitudinal [¹¹C]UCB-J µPET/CT scans were acquired in Sapap3 ko and wildtype (wt) contro

SUBMITTER: Glorie D 

PROVIDER: S-EPMC7666267 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature