Cardiotoxicity of Use of Sequential Aromatase Inhibitors in Women With Breast Cancer.

ABSTRACT: The association between use of aromatase inhibitors (AIs) and cardiovascular outcomes is controversial. While some observational studies have assessed the cardiovascular safety of AIs as upfront treatments, their cardiotoxicity as sequential treatments with tamoxifen remains unknown. Thus, we conducted a population-based cohort study using data from the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics and Office for National Statistics databases. We employed a prevalent new-user design to propensity-score match, in a 1:2 ratio, patients switching from tamoxifen to AIs with patients continuing tamoxifen between 1998 and 2016. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for the study outcomes (my

SUBMITTER: Khosrow-Khavar F 

PROVIDER: S-EPMC7666418 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature