Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Observational studies consistently report inverse associations between cancer and Alzheimer disease (AD). Shared inverse etiological mechanisms might explain this phenomenon, but a systematic evaluation of methodological biases in existing studies is needed.

Objectives

To systematically review and meta-analyze evidence on the association between cancer and subsequent AD, systematically identify potential methodological biases in studies, and estimate the influence of these biases on the estimated pooled association between cancer and AD.

Data sources

All-language publications were identified from PubMed, Embase, and PsycINFO databases through September 2, 2020.

Study selection

Longitudinal cohort studies and case-control studies on the risk of AD in

SUBMITTER: Ospina-Romero M 

PROVIDER: S-EPMC7666424 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature