Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease.

ABSTRACT:

Background

We previously found temporoparietal-predominant atrophy patterns in the behavioral variant of Alzheimer's disease (bvAD), with relative sparing of frontal regions. Here, we aimed to understand the clinico-anatomical dissociation in bvAD based on alternative neuroimaging markers.

Methods

We retrospectively included 150 participants, including 29 bvAD, 28 "typical" amnestic-predominant AD (tAD), 28 behavioral variant of frontotemporal dementia (bvFTD), and 65 cognitively normal participants. Patients with bvAD were compared with other diagnostic groups on glucose metabolism and metabolic connectivity measured by [¹⁸F]FDG-PET, and on subcortical gray matter and white matter hyperintensity (WMH) volumes measured by MRI. A receiver-operating-characteristic-a

SUBMITTER: Singleton EH 

PROVIDER: S-EPMC7666520 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature