Molecular exploration of paediatric intracranial germinomas from multi-ethnic Singapore.

ABSTRACT:

Background

Germinomas (IG) account for up to 50% of all intracranial germ cell tumours. These tumours are reputed to be more prevalent in Oriental populations in comparison to Western cohorts. Biological characteristics of IG in other ethnic groups are unknown. Singapore is a multi-ethnic country with diverse cultures. Owing to inter-racial heterogeneity, the authors hypothesize there are molecular differences between paediatric IG patients in our local population. The aims of this study are exploratory: firstly, to identify molecular characteristics in this tumour type and circulating CSF unique to different racial cohorts; and next, to corroborate our findings with published literature.

Methods

This is a single-institution, retrospective study of prospectively collected da

SUBMITTER: Low SYY 

PROVIDER: S-EPMC7666528 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature