Functional investigation of the coronary artery disease gene SVEP1.

ABSTRACT: A missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) and vascular smooth muscle cells to represent the major cellular source of SVEP1 in plaques. Plaques were larger in atherosclerosis-prone Svep1 haploinsufficient (ApoE^-/-Svep1^+/-) compared to Svep1 wild-type mice (ApoE^-/-Svep1^+/+) and ApoE^-/-Svep1^+/- mice displayed elevated plaque neutrophil, Ly6C^high monocyte, and macrophage numbers. We assessed how leukocytes accumulated more inside plaques in ApoE^-/-Svep1^+/- mic

SUBMITTER: Winkler MJ 

PROVIDER: S-EPMC7666586 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature