Use of patient-specific computational models for optimization of aortic insufficiency after implantation of left ventricular assist device.

ABSTRACT:

Objective

Aortic incompetence (AI) is observed to be accelerated in the continuous-flow left ventricular assist device (LVAD) population and is related to increased mortality. Using computational fluid dynamics (CFD), we investigated the hemodynamic conditions related to the orientation of the LVAD outflow in these patients.

Method

We identified 10 patients with new aortic regurgitation, and 20 who did not, after LVAD implantation between 2009 and 2018. Three-dimensional models of patients' aortas were created from their computed tomography scans. The geometry of the LVAD outflow graft in relation to the aorta was quantified using azimuth angles (AA), polar angles (PAs), and distance from aortic root. The models were used to run CFD simulations, which calculated the pressure

SUBMITTER: Kasinpila P 

PROVIDER: S-EPMC7666659 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature